Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway

Viruses. 2013 Dec 16;5(12):3192-212. doi: 10.3390/v5123192.


As viruses do not possess genes encoding for proteins required for translation, energy metabolism or membrane biosynthesis, they are classified as obligatory intracellular parasites that depend on a host cell to replicate. This genome limitation forces them to gain control over cellular processes to ensure their successful propagation. A diverse spectrum of virally encoded proteins tackling a broad spectrum of cellular pathways during most steps of the viral life cycle ranging from the host cell entry to viral protein translation has evolved. Since the host cell PI3K/Akt signaling pathway plays a critical regulatory role in many cellular processes including RNA processing, translation, autophagy and apoptosis, many viruses, in widely varying ways, target it. This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3-Phosphoinositide-Dependent Protein Kinases / metabolism*
  • Host-Pathogen Interactions*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*
  • Virus Physiological Phenomena*


  • 3-Phosphoinositide-Dependent Protein Kinases
  • Proto-Oncogene Proteins c-akt