Whipple's disease confined to the central nervous system

Ann Neurol. 1987 Jan;21(1):104-8. doi: 10.1002/ana.410210121.


Progressive hypersomnia, memory disturbance, and vertical ophthalmoplegia developed in a 63-year-old woman. The diagnosis of Whipple's disease of the central nervous system was suggested by her presentation and results of studies using magnetic resonance imaging. Despite a one-month course of antibiotics, active Whipple's disease, localized to the central nervous system, was found at autopsy.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / therapeutic use
  • Brain / pathology*
  • Central Nervous System Diseases / diagnosis
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / pathology*
  • Female
  • Humans
  • Microscopy, Electron
  • Middle Aged
  • Whipple Disease / diagnosis
  • Whipple Disease / drug therapy
  • Whipple Disease / pathology*


  • Anti-Infective Agents