NF-κB control of T cell development

Nat Immunol. 2014 Jan;15(1):15-25. doi: 10.1038/ni.2785.


The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Lineage / immunology
  • Humans
  • Models, Immunological
  • NF-kappa B / immunology*
  • NF-kappa B / metabolism
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism
  • Signal Transduction / immunology*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Thymocytes / cytology
  • Thymocytes / immunology*
  • Thymocytes / metabolism


  • NF-kappa B
  • Receptors, Antigen, T-Cell