(+)-Catechin attenuates activation of hepatic stellate cells

Cell Biol Int. 2014 Apr;38(4):526-30. doi: 10.1002/cbin.10228. Epub 2014 Jan 10.


(+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.

Keywords: catechin; hepatic stellate cell; inflammation; liver fibrosis; peroxisome proliferator-activated receptor γ; type I collagen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catechin / pharmacology*
  • Cell Line
  • Collagen Type I / genetics
  • Collagen Type I / metabolism
  • Cytokines / metabolism
  • Down-Regulation / drug effects
  • Hepatic Stellate Cells / cytology
  • Hepatic Stellate Cells / drug effects*
  • Interleukin-10 / metabolism
  • Lipids / biosynthesis
  • Mice
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • RNA, Messenger / metabolism
  • Stereoisomerism
  • Up-Regulation / drug effects


  • Collagen Type I
  • Cytokines
  • Lipids
  • PPAR gamma
  • RNA, Messenger
  • Interleukin-10
  • Catechin