Novel insights on interactions between folate and lipid metabolism

Biofactors. 2014 May-Jun;40(3):277-83. doi: 10.1002/biof.1154. Epub 2013 Dec 18.


Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation reactions that are used for post-translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non-alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid-related folate research.

Keywords: NASH; choline; folate; one-carbon metabolism; phospholipids; steatosis; triacylglycerol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / blood
  • Atherosclerosis / drug therapy
  • Dietary Supplements
  • Epigenesis, Genetic / drug effects
  • Folic Acid / pharmacology
  • Folic Acid / physiology*
  • Folic Acid / therapeutic use
  • Humans
  • Lipid Metabolism*
  • Liver / drug effects
  • Liver / metabolism
  • Obesity / blood
  • Obesity / drug therapy


  • Folic Acid