Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

Oncoimmunology. 2013 Oct 1;2(10):e26286. doi: 10.4161/onci.26286. Epub 2013 Oct 10.


The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication.

Keywords: PD-1 blockade; adoptive immunotherapy; cancer; chimeric antigen receptor; immune response.