Osteoporotic fracture healing: potential use of medicinal plants from the tropics

Curr Drug Targets. 2013 Dec;14(14):1651-8. doi: 10.2174/1389450114666131217113759.


With improvements in living standards and healthcare, life expectancy has been increasing dramatically in most parts of the world. These situations lead to the increase in the reported cases of geriatrics-related diseases such as hypogonadal osteoporosis with skeletal fracture being the ultimate outcome, which eventually causes significant morbidity and mortality. The deficient gonadal hormones, which are the main cause of hypogonadal osteoporosis, could be substituted with hormone replacement therapy to hinder bone loss. However, the artificial hormonal therapy has been linked to grievous conditions such as breast and prostate cancers. In view of the various adverse effects associated with conventional treatment, many researchers are now focusing on finding alternative remedies from nature. This article explores the possibilities of certain medicinal plants native to Malaysia that possess androgenic and antioxidant properties to potentially be used in the treatment of fracture due to osteoporosis in ageing people.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Fracture Healing / drug effects*
  • Fractures, Bone / drug therapy*
  • Fractures, Bone / etiology
  • Fractures, Bone / metabolism
  • Hormone Replacement Therapy
  • Humans
  • Malaysia
  • Medicine, East Asian Traditional
  • Osteoporosis / complications*
  • Osteoporosis / drug therapy
  • Osteoporosis / metabolism
  • Oxidative Stress / drug effects
  • Plant Preparations / administration & dosage
  • Plant Preparations / therapeutic use*
  • Plants, Medicinal*


  • Antioxidants
  • Plant Preparations