Neutrophil microparticles modulate cytokine production by natural killer cells

Boris K Pliyev; Mariya V Kalintseva; Sofya V Abdulaeva; Konstantin N Yarygin; Valery G Savchenko

doi:10.1016/j.cyto.2013.11.010

Neutrophil microparticles modulate cytokine production by natural killer cells

Cytokine. 2014 Feb;65(2):126-9. doi: 10.1016/j.cyto.2013.11.010. Epub 2013 Dec 16.

Authors

Boris K Pliyev¹, Mariya V Kalintseva², Sofya V Abdulaeva³, Konstantin N Yarygin³, Valery G Savchenko²

Affiliations

¹ Hematology Research Center, Novy Zykovsky Pr. 4, Moscow 125167, Russia. Electronic address: bpliyev@cardio.ru.
² Hematology Research Center, Novy Zykovsky Pr. 4, Moscow 125167, Russia.
³ Institute of Biomedical Chemistry, Pogodinskaya Str. 10, Moscow 119121, Russia.

PMID: 24355430
DOI: 10.1016/j.cyto.2013.11.010

Abstract

Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α but enhanced the release of TGF-β1 by IL-2/IL-12-activated NK cells. The inhibitory effect of NMs was strongly attenuated by blockade of phosphatidylserine exposed on NMs. Thus, NMs skew the cytokine profile of NK cells from pro-inflammatory toward anti-inflammatory, potentially favoring the resolution of inflammation.

Keywords: Cytokines; NK cells; Neutrophil microparticles; Phosphatidylserine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell-Derived Microparticles / metabolism*
Cytokines / biosynthesis*
Humans
Killer Cells, Natural / metabolism*
Neutrophils / cytology*
Neutrophils / metabolism*
Phosphatidylserines / metabolism

Substances

Cytokines
Phosphatidylserines