Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after exposure to 60Co gamma-rays, 241Am alpha-particles or bleomycin

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Feb;51(2):209-18. doi: 10.1080/09553008714550711.

Abstract

The rejoining of DNA double strand breaks (dsb) induced by 60Co gamma-rays, 241Am alpha-particles or bleomycin was measured by neutral filter elution. In agreement with their colony-forming ability, ataxia-telangiectasia cells (AT2BE) and normal fibroblasts exhibited similar dsb rejoining capacity following alpha-irradiation, but showed marked differences in the rejoining kinetics of dsb induced by gamma-rays or bleomycin.

MeSH terms

  • Alpha Particles
  • Ataxia Telangiectasia / genetics*
  • Bleomycin / toxicity*
  • Cell Division / drug effects
  • Cell Division / radiation effects
  • Cells, Cultured
  • DNA / radiation effects
  • DNA Damage*
  • DNA Repair*
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Gamma Rays
  • Humans
  • Kinetics

Substances

  • Bleomycin
  • DNA