Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors

EMBO Rep. 2014 Jan;15(1):103-9. doi: 10.1002/embr.201337371. Epub 2013 Dec 15.


The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium Signaling
  • Cerebellum / cytology
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Postsynaptic Potentials
  • Glycine / analogs & derivatives
  • Glycine / pharmacology
  • HEK293 Cells
  • Humans
  • Ion Channel Gating
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Purkinje Fibers / drug effects
  • Purkinje Fibers / physiology
  • Receptors, Glutamate / metabolism*
  • Receptors, Metabotropic Glutamate / metabolism*
  • Resorcinols / pharmacology


  • Excitatory Amino Acid Agonists
  • Receptors, Glutamate
  • Receptors, Metabotropic Glutamate
  • Resorcinols
  • glutamate receptor delta 2
  • 3,5-dihydroxyphenylglycine
  • Glycine