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. 2014 Jan;63(1):48-9.
doi: 10.2337/db13-1478.

Endoplasmic Reticulum: An Interface Between the Immune System and Metabolism

Free PMC article

Endoplasmic Reticulum: An Interface Between the Immune System and Metabolism

Emil R Unanue et al. Diabetes. .
Free PMC article


Figure 1
Figure 1
ER is an interface between the immune system and metabolism. ER is an intersection between inflammation and metabolism and an attractive target for immunometabolic diseases, including type 1 and type 2 diabetes, atherosclerosis, and Wolfram syndrome.

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    1. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011;334:1081–1086 - PubMed
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    1. Oslowski CM, Urano F. The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol 2011;23:207–215 - PMC - PubMed
    1. Fonseca SG, Fukuma M, Lipson KL, et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem 2005;280:39609–39615 - PubMed
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