Deducing protein function by forensic integrative cell biology

PLoS Biol. 2013 Dec;11(12):e1001742. doi: 10.1371/journal.pbio.1001742. Epub 2013 Dec 17.


Our ability to sequence genomes has provided us with near-complete lists of the proteins that compose cells, tissues, and organisms, but this is only the beginning of the process to discover the functions of cellular components. In the future, it's going to be crucial to develop computational analyses that can predict the biological functions of uncharacterised proteins. At the same time, we must not forget those fundamental experimental skills needed to confirm the predictions or send the analysts back to the drawing board to devise new ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biochemistry / methods
  • Cell Biology* / organization & administration
  • Cytological Techniques
  • Genomics
  • Humans
  • Proteins / physiology*


  • Proteins