[Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis]

Ideggyogy Sz. 2013 Sep 30;66(9-10):293-303.
[Article in Hu]

Abstract

The world-wide incidence of vitamin D deficiency is high, independently of age. Multiple sclerosis is a chronic disorder, occuring in those who possess or are exposed to a combination of genetic and environmental risk factors. One of the environmental factors associated with the development is vitamin D. Vitamin D is an immunomodulatory agent, its role is verified in many of autoimmune diseases. Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production. Moreover it enhances the immunosuppressive IL-10 cytokine secretion and inhibits the T-reg cell development. These cytokines and cells are essential for the pathomechanism of multiple sclerosis. Data have shown, that the vitamin D levels above 100 nmol/l (40 ng/ml) is essential for the prevention of multiple sclerosis. Below this level the vitamin D supplementation is reasonable. In pregnancy, the vitamin D deficiency at the last two semester increases the risk for the multiple sclerosis of the infant. The optimal vitamin D level for multiple sclerosis patients is 100-150 nmol/l (40-60 ng/ml). There is no consensus for the role of vitamin D in multiple sclerosis yet, but until the achieving this, the diagnosis and the treatment of the vitamin D deficiency is crucial for scelrosis multiplex patients and in cases of elevated risk. Data shows, that in patient with multiple sclerosis the normal vitamin D level is suboptimal, however the exact role of vitamin D and doses must be clarified by interventional studies.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Dementia / drug therapy
  • Dietary Supplements
  • Drug Administration Schedule
  • Female
  • Humans
  • Hypercalcemia / chemically induced
  • Immunologic Factors / therapeutic use*
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / prevention & control*
  • Pregnancy
  • Pregnancy Complications / immunology
  • Pregnancy Complications / prevention & control
  • Sunlight
  • Vitamin D / administration & dosage
  • Vitamin D / adverse effects
  • Vitamin D / immunology*
  • Vitamin D / pharmacology
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / drug therapy*
  • Vitamin D Deficiency / epidemiology*
  • Vitamin D Deficiency / etiology
  • Vitamin D Deficiency / metabolism
  • Vitamins / immunology
  • Vitamins / therapeutic use

Substances

  • Immunologic Factors
  • Vitamins
  • Vitamin D