Tubulointerstitial injury associated with chemotherapeutic agents

Adv Chronic Kidney Dis. 2014 Jan;21(1):56-63. doi: 10.1053/j.ackd.2013.06.010.


Chemotherapy holds tremendous potential in improving the survival of patients with cancer. However, the side effects of these drugs, including those that affect the kidney, can adversely affect patient outcomes. Prompt recognition of these adverse kidney effects allows early intervention that can minimize or prevent patient morbidity. In this review, we examine the nephrotoxic potential of chemotherapy drugs. In concentrating on tubulointerstitial injury, we will review common agents that result in acute kidney injury due to acute tubular necrosis, tubulopathies, crystal nephropathy, acute interstitial nephritis, and chronic interstitial nephritis, and we will present preventive and management strategies.

Keywords: Acute kidney injury; Chemotherapy; Chronic kidney disease; Fanconi syndrome.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Age Factors
  • Antineoplastic Agents / adverse effects*
  • Diabetes Insipidus, Nephrogenic / chemically induced
  • Fanconi Syndrome / chemically induced
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Tubular Necrosis, Acute / chemically induced
  • Neoplasms / drug therapy*
  • Nephritis, Interstitial / chemically induced
  • Renal Insufficiency, Chronic / chemically induced
  • Sex Factors


  • Antineoplastic Agents