Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

Nature. 1987 Mar 26-Apr 1;326(6111):358-63. doi: 10.1038/326358a0.


The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of antigen-antibody binding. The structure of the antigen changes on binding, and that of the antibody may also change; the interaction therefore has some of the character of a handshake.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Antibodies, Viral / immunology
  • Antigen-Antibody Complex*
  • Antigens, Viral / immunology
  • Epitopes / immunology
  • Immunoglobulin Fab Fragments / immunology*
  • Immunoglobulin Variable Region
  • Macromolecular Substances
  • Microscopy, Electron
  • Neuraminidase / immunology*
  • Orthomyxoviridae / enzymology*
  • Orthomyxoviridae / immunology
  • Protein Conformation


  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Antigens, Viral
  • Epitopes
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Variable Region
  • Macromolecular Substances
  • Neuraminidase