GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits

Neuron. 2013 Dec 18;80(6):1368-83. doi: 10.1016/j.neuron.2013.10.016.


Recent development of molecular genetic techniques are rapidly advancing understanding of the functional role of brain circuits in behavior. Critical to this approach is the ability to target specific neuron populations and circuits. The collection of over 250 BAC Cre-recombinase driver lines produced by the GENSAT project provides a resource for such studies. Here we provide characterization of GENSAT BAC-Cre driver lines with expression in specific neuroanatomical pathways within the cerebral cortex and basal ganglia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basal Ganglia / metabolism*
  • Cerebral Cortex / metabolism*
  • Chromosomes, Artificial, Bacterial / genetics*
  • Databases, Genetic
  • Gene Expression / genetics
  • Genes, Reporter / genetics
  • Integrases / genetics*
  • Integrases / metabolism*
  • Mice
  • Mice, Transgenic
  • Models, Neurological
  • Molecular Imaging / methods
  • Neural Pathways / metabolism*
  • Neurons / metabolism


  • Cre recombinase
  • Integrases