Metabolic syndrome in patients with prostate cancer undergoing androgen suppression

Actas Urol Esp. 2014 Jun;38(5):285-9. doi: 10.1016/j.acuro.2013.09.008. Epub 2013 Dec 20.
[Article in English, Spanish]


Objectives: Cardiovascular mortality is the leading cause of death in patients with prostate cancer (PC), metabolic syndrome (MS) being related to it. The main objective of this study was to determine the prevalence of MS in patients with CP undergoing androgen suppression (AS).

Material and methods: We performed a retrospective study of cases and controls that included 159 patients. The study group was made up of 53 patients with PC undergoing SA for a period exceeding 12 months. The control group was formed by 53 patients with PC at the time of diagnosis and 53 patients with negative prostate biopsy. All patients were evaluated for presence of MS according to NCEP-ATPIII criteria.

Results: Prevalence of MS in patients without PC was 32.1% and in those with non-treated PC 35.8%, P = .324. In patients with PC undergoing AS, prevalence of MS was 50.9%, P < .001. When AS duration was less than 36 months, prevalence of MS was 44.0% and when greater than 36 months 57.1%, P < .001. Waist circumference and hyperglycemia were the two MS components that significantly increased. AS and its duration were independent predictors factors for the development of MS.

Conclusions: Continuous AS therapy increases the prevalence of MS and especially waist circumference and hyperglycemia. Development of MS increases according to AS duration.

Keywords: Androgen suppression; Cáncer de próstata; Metabolic syndrome; Prostate cancer; Supresión androgénica; Síndrome metabólico.

MeSH terms

  • Aged
  • Androgen Antagonists / adverse effects*
  • Androgen Antagonists / therapeutic use
  • Case-Control Studies
  • Humans
  • Male
  • Metabolic Syndrome / chemically induced*
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Prevalence
  • Prostatic Neoplasms / drug therapy*
  • Retrospective Studies


  • Androgen Antagonists