Comparison of circuit patency and exchange rates between 2 different continuous renal replacement therapy machines

J Crit Care. 2014 Apr;29(2):272-7. doi: 10.1016/j.jcrc.2013.11.012. Epub 2013 Nov 25.


Background: Continuous renal replacement therapy (CRRT) is an important tool in the care of critically ill patients. However, the impact of a specific CRRT machine type on the successful delivery of CRRT is unclear. The purpose of this study was to evaluate the effectiveness of CRRT delivery with an intensive care unit (ICU) bedside nurse delivery model for CRRT while comparing circuit patency and circuit exchange rates in 2 Food and Drug Administration-approved CRRT devices. This article presents the data comparing circuit exchange rates for 2 different CRRT machines.

Materials and methods: A group of ICU nurses were selected to undergo expanded training in CRRT operation and empowered to deliver all aspects of CRRT. The ICU nurses then provided all aspects of CRRT on 2 Food and Drug Administration-approved CRRT devices for 6 months. Each device was used exclusively in the designated ICU for a 2-week run-in period followed by 3-month data collection period. The primary end point for the study was the differences in average number of filter exchanges per day during each CRRT event.

Results: A total of 45 unique patients who underwent 64 separate CRRT treatment periods were included. Four CRRT events were excluded (see text for details). Twenty-eight CRRT events occurred in the NxStage System One arm (NxStage Medical, Lawrence, Mass) and 32 events in the Gambro Prismaflex arm (Gambro Renal Products, Boulder, Colo). Average (SD) filter exchanges per day was 0.443 (0.60) for the NxStage System One machine and 0.553 (0.65) for Gambro Prismaflex machine (P = .09).

Conclusions: There was no demonstrable difference in circuit patency as defined by the rate of filter exchanges per day of CRRT therapy.

Keywords: Circuit survival; Continuous renal replacement therapy; Filter exchange; Gambro Prismaflex machine; NxStage System One machine; Quality improvement.

Publication types

  • Comparative Study

MeSH terms

  • Acute Kidney Injury / mortality
  • Acute Kidney Injury / therapy*
  • Aged
  • Critical Care Nursing / education*
  • Critical Illness
  • Cross-Over Studies
  • Equipment Failure Analysis / statistics & numerical data
  • Female
  • Filtration / instrumentation*
  • Filtration / statistics & numerical data
  • Hemodialysis Solutions
  • Hospital Mortality
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality Improvement
  • Renal Replacement Therapy / instrumentation*
  • Renal Replacement Therapy / methods
  • Renal Replacement Therapy / mortality
  • Renal Replacement Therapy / nursing


  • Hemodialysis Solutions