Apamin depresses selectively the after-hyperpolarization of cat spinal motoneurons

Neurosci Lett. 1987 Feb 10;74(1):58-62. doi: 10.1016/0304-3940(87)90051-6.

Abstract

Extra- (but not intra-) -cellularly applied apamin depresses selectively the after-hyperpolarization (AHP) of cat spinal motoneurons in situ, while causing only a slight depolarization and minor changes in size and shape of the action potential. Apamin increases firing evoked by long depolarizing current pulses. These results indicate that the Ca2+-dependent K conductance underlying the AHP is sensitive to apamin, and that this conductance is likely to have a physiological role in the control of motoneuronal firing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apamin / pharmacology*
  • Bee Venoms / pharmacology*
  • Cats
  • Electric Conductivity
  • Female
  • Ion Channels / drug effects
  • Male
  • Membrane Potentials / drug effects
  • Motor Neurons / drug effects*
  • Potassium / metabolism
  • Spinal Cord / drug effects*

Substances

  • Bee Venoms
  • Ion Channels
  • Apamin
  • Potassium