Tissue-engineered kidney disease models

Abstract

Renal disease represents a major health problem that often results in end-stage renal failure necessitating dialysis and eventually transplantation. Historically these diseases have been studied with patient observation and screening, animal models, and two-dimensional cell culture. In this review, we focus on recent advances in tissue engineered kidney disease models that have the capacity to compensate for the limitations of traditional modalities. The cells and materials utilized to develop these models are discussed and tissue engineered models of polycystic kidney disease, drug-induced nephrotoxicity, and the glomerulus are examined in detail. The application of these models has the potential to direct future disease treatments and preclinical drug development.

Keywords: 3D tissues; Acute kidney injury; Chronic kidney disease; Drug-induced nephrotoxicity; Glomerulus; Microfluidics; Polycystic kidney disease; Renal; Renal cell carcinoma; Renal fibrosis.