Abstract
The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of infection. G targets the ciliated cells of the airways, and F causes the virion membrane to fuse with the target cell membrane. The F protein is the major target for antiviral drug development, and both G and F glycoproteins are the antigens targeted by neutralizing antibodies induced by infection. In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / immunology*
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Cilia / immunology
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Cilia / virology
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Humans
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Models, Molecular
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Protein Conformation
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Receptors, Virus / chemistry
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Receptors, Virus / physiology
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Respiratory Mucosa / immunology
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Respiratory Mucosa / virology
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Respiratory Syncytial Virus Infections / immunology
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Respiratory Syncytial Virus Infections / prevention & control*
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Respiratory Syncytial Virus Vaccines / administration & dosage
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Respiratory Syncytial Virus Vaccines / immunology*
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Respiratory Syncytial Virus, Human / chemistry*
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Respiratory Syncytial Virus, Human / drug effects
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Respiratory Syncytial Virus, Human / immunology
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Viral Fusion Proteins / antagonists & inhibitors
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Viral Fusion Proteins / chemistry*
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Viral Fusion Proteins / physiology
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Virion / chemistry
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Virion / physiology
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Antiviral Agents
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F protein, human respiratory syncytial virus
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G glycoprotein, Respiratory syncytial virus
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Receptors, Virus
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Respiratory Syncytial Virus Vaccines
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Viral Fusion Proteins