Management of vestibular schwannomas with linear accelerator-based stereotactic radiosurgery: a single center experience

Tumori. 2013 Sep-Oct;99(5):617-22. doi: 10.1177/030089161309900510.


Aims and background: The primary goal of treatment for vestibular schwannoma is to achieve local control without comprimising regional cranial nerve function. Stereotactic radiosurgery has emerged as a viable therapeutic option for vestibular schwannoma. The aim of the study is to report our 15-year single center experience using linear accelerator-based stereotactic radiosurgery in the management of patients with vestibular schwannoma.

Methods and study design: Between July 1998 and January 2013, 68 patients with unilateral vestibular schwannoma were treated using stereotactic radiosurgery at the Department of Radiation Oncology, Gulhane Military Medical Academy. All patients underwent high-precision stereotactic radiosurgery using a linear accelerator with 6-MV photons.

Results: Median follow-up time was 51 months (range, 9-107). Median age was 45 years (range, 20-77). Median dose was 12 Gy (range, 10-13) prescribed to the 85%-95% isodose line encompassing the target volume. Local tumor control in patients with periodic follow-up imaging was 96.1%. Overall hearing preservation rate was 76.5%.

Conclusions: Linear accelerator-based stereotactic radiosurgery offers a safe and effective treatment for patients with vestibular schwannoma by providing high local control rates along with improved quality of life through well-preserved hearing function.

MeSH terms

  • Adult
  • Aged
  • Female
  • Hearing*
  • Humans
  • Male
  • Middle Aged
  • Neuroma, Acoustic / physiopathology
  • Neuroma, Acoustic / surgery*
  • Quality of Life*
  • Radiosurgery*
  • Radiotherapy Dosage
  • Treatment Outcome