The pertussis problem

Clin Infect Dis. 2014 Mar;58(6):830-3. doi: 10.1093/cid/cit934. Epub 2013 Dec 20.


Pertussis is resurgent, and many cases are occurring in vaccinated children and adolescents. In countries using acellular vaccines, waning immunity is at least part of the problem. This article discusses possible improvements in those vaccines.

Keywords: Th1 responses; adjuvants; pertussis; pertussis toxin; waning immunity.

MeSH terms

  • Antibodies, Bacterial / immunology
  • Humans
  • Pertussis Toxin / immunology
  • Pertussis Vaccine / administration & dosage*
  • Pertussis Vaccine / immunology
  • Whooping Cough / immunology*
  • Whooping Cough / prevention & control*


  • Antibodies, Bacterial
  • Pertussis Vaccine
  • Pertussis Toxin