Objective: To investigate the expression of glucose-regulated protein78 (GRP78) in human laryngeal squamous cell carcinoma,and to evaluate its role in the development progress of human laryngeal squamous cell carcinoma.
Method: The expressions of GRP78 in human laryngeal squamous cell carcinoma, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue from 90 patients were detected using immunohistochemistry analysis. In addition, the relationship between GRP78 expression and clinical parameters of patients, such as gender, tumor differentiation grade stage, and lymphatic metastasis was analyzed.
Result: The positive ratio of GRP78 expression in LSCC, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue were 86.67%, 32.22% and 8.89%. The GRP78 expressions in different tissues were significantly different (P < 0.05). GRP78 expression in LSCC tissues was correlated with the grade of differention (P < 0.05), stage of tumors (P < 0.05), and lymphatic metastasis (P < 0.05), but not with gender (P > 0.05).
Conclusion: The expression level of GRP78 protein in human laryngeal squamous cell carcinoma is high and its expression is positively associated with the malignancy of carcinoma. The expression of GRP78 protein participates in the development progress of human laryngeal squamous cell carcinoma.