Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection--genetic aspects

Ann Agric Environ Med. 2013;20(4):711-4.


Influenza is a contagious respiratory disease caused by viruses belonging to the family Ortomyxoviridae. Among the influenza viruses type A, B and C, the A type virus shows the most pathogenic potential. Its surface receptor glycoproteins, hemagglutinin (HA) and neuraminidase (NA), are characterized by high antigenic variation, thus a host organism cannot develop permanent resistance. The case is described of a male patient with severe acute respiratory distress syndrome in the course of influenza A/N1H1v infection, confirmed by virological molecular analysis. During diagnostic procedures based on the MSSCP genotyping it was observed that the WHO recommended RT-PCR kits and/or procedure of sample collection from patients for molecular investigation could lead to false positive A/H1N1 pandemic strain detection because of the co-amplification during the RT-PCR fragments of the human genome.

Publication types

  • Case Reports

MeSH terms

  • Fatal Outcome
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza, Human / complications*
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Respiratory Distress Syndrome / etiology*