Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO

Hannah Baars; Astrid Beyer; Stefanie V Kohlhepp; Carsten Bolm

doi:10.1021/ol403414v

Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO

Org Lett. 2014 Jan 17;16(2):536-9. doi: 10.1021/ol403414v. Epub 2013 Dec 24.

Authors

Hannah Baars¹, Astrid Beyer, Stefanie V Kohlhepp, Carsten Bolm

Affiliation

¹ Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, D-52074 Aachen, Germany.

PMID: 24364511
DOI: 10.1021/ol403414v

Abstract

Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields.