Neuronal rebound spiking, resonance frequency and theta cycle skipping may contribute to grid cell firing in medial entorhinal cortex

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20120523. doi: 10.1098/rstb.2012.0523. Print 2014 Feb 5.


Data show a relationship of cellular resonance and network oscillations in the entorhinal cortex to the spatial periodicity of grid cells. This paper presents a model that simulates the resonance and rebound spiking properties of entorhinal neurons to generate spatial periodicity dependent upon phasic input from medial septum. The model shows that a difference in spatial periodicity can result from a difference in neuronal resonance frequency that replicates data from several experiments. The model also demonstrates a functional role for the phenomenon of theta cycle skipping in the medial entorhinal cortex.

Keywords: entorhinal cortex; grid cells; head direction; place cells; rat; theta rhythm.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetylcholine / pharmacology
  • Action Potentials / physiology*
  • Animals
  • Computer Simulation
  • Entorhinal Cortex / cytology
  • Entorhinal Cortex / physiology*
  • Models, Neurological*
  • Neurons / cytology
  • Neurons / physiology*
  • Space Perception / physiology*
  • Theta Rhythm / physiology*


  • Acetylcholine