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Comment
. 2014 Jan 7;111(1):7-8.
doi: 10.1073/pnas.1321881111. Epub 2013 Dec 23.

Mitochondria Impact Brain Function and Cognition

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Mitochondria Impact Brain Function and Cognition

Martin Picard et al. Proc Natl Acad Sci U S A. .
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Conflict of interest statement

The authors declare no conflict of interest.

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Fig. 1.
Fig. 1.
Schematic representation of presynaptic mitochondria in the mammalian brain and their effect on synaptic remodeling. Donut-shaped mitochondria are negative neuromodulators associated with smaller active zones and fewer docked vesicles in the dorsolateral prefrontal cortex (dlPFC) of monkeys and correlated with poor delayed response memory. (Inset) Donut mitochondria form by curvature and self-fusion of preexisting mitochondrial tubules (10, 11).

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