History of having a macrosomic infant and the risk of diabetes: the Japan public health center-based prospective diabetes study

PLoS One. 2013 Dec 19;8(12):e84542. doi: 10.1371/journal.pone.0084542. eCollection 2013.


Objective: The aim of the present study was to test a hypothesis that a history of having a macrosomic infant (≥ 4000 g) is associated with the risk of diabetes.

Methods: Data on the Japan Public Health Center-based Prospective diabetes cohort were analyzed, which is a population-based cohort study on diabetes. The survey of diabetes was performed at baseline and at the 5-year follow-up. A history of having a macrosomic infant was assessed using a self-administered questionnaire. A cross-sectional analysis was performed among 12,153 women who participated in the 5-year survey of the cohort. Logistic regression was used to examine the relationship between a history of having a macrosomic infant and the presence of diabetes. A longitudinal analysis was also conducted among 7,300 women without diabetes who participated in the baseline survey. Logistic regression was used to investigate the relationship between a history of having a macrosomic infant and the incidence of diabetes between the baseline survey and the 5-year survey.

Results: In the cross-sectional analysis, parous women with a positive history were more likely to have diabetes in relation to parous women without (OR = 1.44, 95% CI = 1.13-1.83). The longitudinal analysis showed a modest but non-significant increased risk of developing diabetes among women with a positive history (OR = 1.24, 95% CI = 0.80-1.94).

Conclusions: An increased risk of diabetes was implied among women with a history of having a macrosomic infant although the longitudinal analysis showed a non-significant increased risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Fetal Macrosomia* / metabolism
  • Humans
  • Infant
  • Japan / epidemiology
  • Longitudinal Studies
  • Male
  • Prospective Studies
  • Public Health*
  • Reproduction
  • Risk
  • Surveys and Questionnaires

Grant support

This study was supported by Health Sciences Research Grants (Research on Health Services H10-074, Medical Frontier Strategy Research H13-008, Clinical Research for Evidence-based Medicine H14-008 and H15-006, and Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus H16-019, H17-019, H18-028, H19-016, and H25-016) and a grant-in-aid for Cancer Research and a grant-in-aid for the Third Term Comprehensive Ten-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare of Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.