The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells

J Neuroimmunol. 2014 Feb 15;267(1-2):105-10. doi: 10.1016/j.jneuroim.2013.12.004. Epub 2013 Dec 11.

Abstract

Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.

Keywords: Hepatocyte growth factor; Immune regulation; Monocyte-derived dendritic cells; Multiple sclerosis (MS); Neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • B7-H1 Antigen / metabolism
  • Cytokines / metabolism
  • Dendritic Cells / drug effects*
  • Female
  • Flow Cytometry
  • HLA-DR Antigens / metabolism
  • Hepatocyte Growth Factor / pharmacology*
  • Humans
  • Male
  • Middle Aged
  • Monocytes / cytology*
  • Monocytes / drug effects
  • T-Lymphocytes / drug effects
  • Young Adult

Substances

  • B7-H1 Antigen
  • CD274 protein, human
  • Cytokines
  • HLA-DR Antigens
  • Hepatocyte Growth Factor