The effect of exogenous creatine phosphate on myocardial injury after percutaneous coronary intervention

Angiology. 2015 Feb;66(2):163-8. doi: 10.1177/0003319713515996. Epub 2013 Dec 23.

Abstract

Objective: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).

Method: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3.

Results: Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively).

Conclusion: Exogenous CP was helpful to reduce myocardial injury after PCI.

Keywords: creatine phosphate; myocardial injury; percutaneous coronary intervention.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • China
  • Creatine Kinase, MB Form / blood
  • Cytoprotection
  • Drug Administration Schedule
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Myocardial Reperfusion Injury / blood
  • Myocardial Reperfusion Injury / diagnosis
  • Myocardial Reperfusion Injury / etiology
  • Myocardial Reperfusion Injury / prevention & control*
  • Percutaneous Coronary Intervention / adverse effects*
  • Phosphocreatine / administration & dosage*
  • Time Factors
  • Treatment Outcome
  • Troponin I / blood
  • Up-Regulation

Substances

  • Biomarkers
  • Troponin I
  • Phosphocreatine
  • Creatine Kinase, MB Form