Diffusion-weighted imaging and demyelinating diseases: new aspects of an old advanced sequence

AJR Am J Roentgenol. 2014 Jan;202(1):W34-42. doi: 10.2214/AJR.13.11400.


Objective: The purpose of this article is to discuss classic applications in diffusion-weighted imaging (DWI) in demyelinating disease and progression of DWI in the near future.

Conclusion: DWI is an advanced technique used in the follow-up of demyelinating disease patients, focusing on the diagnosis of a new lesion before contrast enhancement. With technical advances, diffusion-tensor imaging; new postprocessing techniques, such as tract-based spatial statistics; new ways of calculating diffusion, such as kurtosis; and new applications for DWI and its spectrum are about to arise.

Publication types

  • Review

MeSH terms

  • Contrast Media
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / pathology
  • Diagnosis, Differential
  • Diffusion Magnetic Resonance Imaging / methods*
  • Disease Progression
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods


  • Contrast Media