Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women

JAMA Ophthalmol. 2014 Mar;132(3):247-52. doi: 10.1001/jamaophthalmol.2013.6241.

Abstract

Importance: To our knowledge, no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract. The total antioxidant capacity (TAC) concept aims to measure the capacity from all antioxidants in the diet by also taking synergistic effects into account.

Objective: To investigate the association between the TAC of the diet and the incidence of age-related cataract in a population-based prospective cohort of middle-aged and elderly women.

Design, setting, and participants: Questionnaire-based nutrition survey within the prospective Swedish Mammography Cohort study, which included 30,607 women (aged 49-83 years) who were observed for age-related cataract incidence for a mean of 7.7 years.

Exposure: The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay.

Main outcomes and measures: Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area.

Results: There were 4309 incident cases of age-related cataracts during the mean 7.7 years of follow-up (234,371 person-years). The multivariable rate ratio in the highest quintile of the TAC of the diet compared with the lowest was 0.87 (95% CI, 0.79-0.96; P for trend = .03). The main contributors to dietary TAC in the study population were fruit and vegetables (44.3%), whole grains (17.0%), and coffee (15.1%).

Conclusions and relevance: Dietary TAC was inversely associated with the risk of age-related cataract. Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging*
  • Antioxidants / administration & dosage*
  • Cataract / diagnosis
  • Cataract / epidemiology*
  • Cataract / prevention & control
  • Cataract Extraction / statistics & numerical data
  • Diet*
  • Feeding Behavior
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Middle Aged
  • Nutrition Surveys
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Sweden / epidemiology
  • Women's Health

Substances

  • Antioxidants