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, 2013, 916497

Cytokines and Chemokines in Irritant Contact Dermatitis


Cytokines and Chemokines in Irritant Contact Dermatitis

Haur Yueh Lee et al. Mediators Inflamm.


Irritant contact dermatitis is a result of activated innate immune response to various external stimuli and consists of complex interplay which involves skin barrier disruption, cellular changes, and release of proinflammatory mediators. In this review, we will focus on key cytokines and chemokines involved in the pathogenesis of irritant contact dermatitis and also contrast the differences between allergic contact dermatitis and irritant contact dermatitis.


Figure 1
Figure 1
Immunological mechanisms in irritant contact dermatitis. Following irritant insult, there is disruption of the epidermal barrier with release of proinflammatory mediators, that is, IL-1 and TNF-α. This results in stimulation of further cytokine and chemokines production, for example, by keratinocytes, fibroblasts, and endothelial cells, upregulation of adhesion molecules on endothelial cells, and the subsequent recruitment of leucocytes thereby perpetuating ongoing inflammation.

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