Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;2013:571420.
doi: 10.1155/2013/571420. Epub 2013 Nov 28.

Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania Somnifera) in Oligospermic Males: A Pilot Study

Affiliations
Free PMC article

Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania Somnifera) in Oligospermic Males: A Pilot Study

Vijay R Ambiye et al. Evid Based Complement Alternat Med. .
Free PMC article

Abstract

Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n = 21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n = 25) in the same protocol. Semen parameters and serum hormone levels were estimated at the end of 90-day treatment. There was a 167% increase in sperm count (9.59 ± 4.37 × 10(6)/mL to 25.61 ± 8.6 × 10(6)/mL; P < 0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL; P < 0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%; P < 0.0001) on day 90 from baseline. The improvement in these parameters was minimal in the placebo-treated group. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo. The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility.

Figures

Figure 1
Figure 1
Serum testosterone levels (ng/mL) in the full-spectrum Ashwagandha root extract-treated and placebo-treated study groups including oligospermic males. **P < 0.0001 as compared to baseline values on Day 0 of the study duration of 12 weeks. Values are expressed as mean ± SD.
Figure 2
Figure 2
Serum LH (mL IU/mL) in the full-spectrum Ashwagandha root extract-treated and placebo-treated study groups including oligospermic males. *P < 0.001 as compared to baseline values on Day 0 of the study duration (12 weeks). Values are expressed as mean ± SD.
Figure 3
Figure 3
(a) Global Assessment Scale for Tolerability (GATE) by patients. (b) Global Assessment Scale for Tolerability (GATE) by physicians.

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles

References

    1. Collins JA. Male infertility: the interpretation of the diagnostic assessment. In: Mishell DR, Lobo RA, Paulsen CA, editors. 1989 The Year Book of Infertility. 45. Chicago, Ill, USA: Year Book Medical Publishers; 1989. p. 271 pages. (The Year book).
    1. Haslett C, Chilvers ER, Boon NA, Colledge NA, editors. Davidson‘s Principles and Practice of Medicine. Edinburgh, UK: Churchill Livingstone; 2002. p. 711 pages.
    1. Brugh VM, Lipshultz LI. Male factor infertility: evaluation and management. Medical Clinics of North America. 2004;88(2):367–385. - PubMed
    1. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia. 2010;42(1):48–56. - PubMed
    1. Mishra RK, Verma HP, Singh N, Singh SK. Male infertility: lifestyle and oriental remedies. Journal of Scientific Research. 2012;56:93–101.

LinkOut - more resources

Feedback