Mechanisms of neurovascular dysfunction in acute ischemic brain

Curr Med Chem. 2014;21(18):2035-42. doi: 10.2174/0929867321666131228223400.


The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology--excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Ischemia / metabolism
  • Brain Ischemia / physiopathology*
  • Cell Communication
  • Extracellular Space / metabolism
  • Humans
  • Oxidative Stress
  • Signal Transduction
  • Stroke / metabolism
  • Stroke / physiopathology*