Long-term follow-up after urethral injection with polyacrylamide hydrogel for female stress incontinence

Acta Obstet Gynecol Scand. 2014 Feb;93(2):209-12. doi: 10.1111/aogs.12283. Epub 2013 Dec 24.


Urethral injection therapy for treatment of stress urinary incontinence has been in use for years, but only a few long-term follow-up studies have been published. Twenty-five women, injected with polyacrylamide hydrogel 8 years earlier, were invited for follow-up. Twenty-four could be contacted; 15 had had no further treatment, seven had been re-operated with placement of mid-urethral slings, and two had been re-injected with polyacrylamide hydrogel. Eleven women attended for objective examination; all non-attenders were interviewed by telephone. Subjectively, in 44% the stress incontinence was cured or much improved, with a positive outcome according to the King's Health Questionnaire. Objectively, all patients had visible polyacrylamide hydrogel deposits on vaginal ultrasonography. No local adverse reactions were seen in the vaginal mucosa. The results of a later mid-urethral sling were unaffected by previous polyacrylamide hydrogel injection.

Keywords: Urethral injection; polyacrylamid hydrogel; stress incontinence; surgical techniques; urethral bulking; urogynecology.

MeSH terms

  • Acrylic Resins / administration & dosage*
  • Acrylic Resins / adverse effects
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Suburethral Slings
  • Surveys and Questionnaires
  • Treatment Outcome
  • Ultrasonography
  • Urethra / pathology
  • Urethra / surgery*
  • Urinary Incontinence, Stress / pathology
  • Urinary Incontinence, Stress / therapy*
  • Vagina / diagnostic imaging*


  • Acrylic Resins
  • polyacrylamide gels