Localization and treatment of familial malignant nonfunctional paraganglioma with iodine-131 MIBG: report of two cases

J Nucl Med. 1987 Apr;28(4):528-31.


Two cases of familial, malignant, nonfunctional paraganglioma are reported. Uptake of iodine-131 metaiodobenzylguanidine ([131I]MIBG) by the tumors and metastases was demonstrated. In the first case, with multicentric and locally invasive disease, [131I]MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. In the second case, with widespread, symptomatic metastatic disease, a therapeutic dose of [131I]MIBG produced palliation of bone pain after the failure of radio- and chemotherapy. Uptake of [131I]MIBG by paragangliomas does not correlate with catecholamine secretory activity. Iodine-131 MIBG should be considered as a therapeutic option in unresectable, malignant paragangliomas which take up this radiopharmaceutical.

Publication types

  • Case Reports

MeSH terms

  • 3-Iodobenzylguanidine
  • Adult
  • Bone Neoplasms / secondary
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / genetics
  • Brain Neoplasms / therapy
  • Carotid Body / diagnostic imaging*
  • Female
  • Humans
  • Iodine Radioisotopes* / therapeutic use
  • Iodobenzenes* / therapeutic use
  • Male
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Palliative Care
  • Paraganglioma / diagnostic imaging*
  • Paraganglioma / genetics
  • Paraganglioma / therapy
  • Radionuclide Imaging
  • Radiotherapy Dosage


  • Iodine Radioisotopes
  • Iodobenzenes
  • 3-Iodobenzylguanidine