Clinical correlation between hypercoagulability and thrombo-embolic phenomena

Kidney Int. 1987 Mar;31(3):830-5. doi: 10.1038/ki.1987.73.


A study of the coagulolytic balance as well as platelet aggregation was carried out in 64 nephrotic patients. The data were correlated, in a prospective attempt, with the clinical demonstration of thrombo-embolic events. Activating factors (factors I, VIIIc, VIIIr:Ag) were increased as well as certain clotting inhibitors, alpha-1-antitrypsin and alpha-2-macroglobulin. There was a platelet hyperaggregability in 31.5% of our patients. Thrombo-embolic complications occurred in six subjects (9%). The data of these six patients were compared with that of the other patients; no significant correlation were found between clotting abnormalities and thrombosis. Low level of ATm (less than 0.8 U.Fr) and severe hypoalbuminemia (less than 20 g/liter) were of no predictive value for the occurrence of thrombo-embolic events.

MeSH terms

  • Adult
  • Aged
  • Antigens / metabolism
  • Antithrombin III / metabolism
  • Blood Coagulation*
  • Factor VIII / immunology
  • Factor VIII / metabolism
  • Female
  • Fibrinogen / metabolism
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nephrotic Syndrome / blood
  • Nephrotic Syndrome / complications*
  • Platelet Aggregation
  • Prospective Studies
  • Serum Albumin / metabolism
  • Thromboembolism / etiology*
  • alpha 1-Antitrypsin / metabolism
  • alpha-Macroglobulins / metabolism
  • von Willebrand Factor


  • Antigens
  • Serum Albumin
  • alpha 1-Antitrypsin
  • alpha-Macroglobulins
  • von Willebrand Factor
  • Antithrombin III
  • Factor VIII
  • Fibrinogen