Protective effect of crude Curcuma longa and its methanolic extract in alloxanized rabbits

Pak J Pharm Sci. 2014 Jan;27(1):121-8.


Curcuma longa (C. longa) is commonly found in different areas of Pakistan. It has been locally utilized as a traditional medicine. The aim of this study was to evaluate the antidiabetic, hepatoprotective and total antioxidant effect of the crude drug and its methanolic extract in rabbits. Diabetes was induced with alloxan (180mg/kg). Two major groups were designed, curative and protective groups. In curative group the crude drug and its methanolic extract was orally administered to the diabetic animals and acute study was performed. On the other hand in protective group the crude drug and its methanolic extract were administered for eight days prior to the diabetes induction. Results indicated that in Curative group the crude and methanolic extract of C. longa significantly improved the levels of serum glucose, serum transaminases and antioxidant activity (AOA). In protective group, serum glucose, serum transaminases were not significantly increased by alloxan, in both crude as well as methanolic extract group. This study shows that C. longa acts as antidiabetic, hepatoprotective and antioxidant in diabetes especially type 1 diabetes.

MeSH terms

  • Alanine Transaminase / blood
  • Alloxan
  • Animals
  • Antioxidants / analysis
  • Antioxidants / pharmacology
  • Blood Glucose / analysis
  • Curcuma*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Liver / drug effects
  • Male
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rabbits


  • Antioxidants
  • Blood Glucose
  • Plant Extracts
  • Alloxan
  • Alanine Transaminase