Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells

Wiley Interdiscip Rev RNA. May-Jun 2014;5(3):335-46. doi: 10.1002/wrna.1214. Epub 2013 Dec 16.

Abstract

Oxidation is probably the most common type of damage that occurs in cellular RNA. Oxidized RNA may be dysfunctional and is implicated in the pathogenesis of age-related human diseases. Cellular mechanisms controlling oxidized RNA have begun to be revealed. Currently, a number of ribonucleases and RNA-binding proteins have been shown to reduce oxidized RNA and to protect cells under oxidative stress. Although information about how these factors work is still very limited, we suggest several mechanisms that can be used to minimize oxidized RNA in various organisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism
  • Humans
  • Oxidation-Reduction
  • Oxidative Stress*
  • Polyribonucleotide Nucleotidyltransferase / metabolism
  • RNA / chemistry
  • RNA / metabolism*
  • RNA Stability

Substances

  • RNA
  • Polyribonucleotide Nucleotidyltransferase
  • DNA-(Apurinic or Apyrimidinic Site) Lyase