Gyrification differences in children and adolescents with velocardiofacial syndrome and attention-deficit/hyperactivity disorder: a pilot study

Sabine E Mous; Canan Karatekin; Chiu-Yen Kao; Irving I Gottesman; Danielle Posthuma; Tonya White

doi:10.1016/j.pscychresns.2013.12.002

Gyrification differences in children and adolescents with velocardiofacial syndrome and attention-deficit/hyperactivity disorder: a pilot study

Psychiatry Res. 2014 Feb 28;221(2):169-71. doi: 10.1016/j.pscychresns.2013.12.002. Epub 2013 Dec 13.

Authors

Sabine E Mous¹, Canan Karatekin², Chiu-Yen Kao³, Irving I Gottesman⁴, Danielle Posthuma⁵, Tonya White⁶

Affiliations

¹ Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC Rotterdam, The Netherlands.
² Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
³ Department of Mathematics, The Ohio State University, Columbus, OH, USA; Department of Mathematical Sciences, Claremont McKenna College, Claremont, CA, USA.
⁴ Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Rotterdam, The Netherlands; Center for Neurogenomics and Cognitive Research, Complex Traits Genetics, VU Amsterdam, The Netherlands; Department of Clinical Genetics, Section on Medical Genomics, VU Medical Centre, Amsterdam, The Netherlands.
⁶ Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Rotterdam, The Netherlands; Department of Radiology, Erasmus MC Rotterdam, The Netherlands. Electronic address: t.white@erasmusmc.nl.

PMID: 24377834
DOI: 10.1016/j.pscychresns.2013.12.002

Abstract

We used magnetic resonance imaging to investigate brain gyrification patterns between 19 children with attention-deficit/hyperactivity disorder (ADHD), 9 children with velocardiofacial syndrome (VCFS), and 23 control children. We found that VCFS is associated with widespread decreases in gyrification. In ADHD, we found minor differences from control children. No evidence was found for common gyrification patterns between VCFS and ADHD children.

Keywords: Attention-deficit/hyperactivity disorder (ADHD); Brain gyrification; Velocardiofacial syndrome (VCFS).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Attention Deficit Disorder with Hyperactivity / complications
Attention Deficit Disorder with Hyperactivity / pathology*
Case-Control Studies
Cerebral Cortex / abnormalities
Cerebral Cortex / pathology*
Child
DiGeorge Syndrome / complications
DiGeorge Syndrome / pathology*
Female
Humans
Magnetic Resonance Imaging*
Male
Pilot Projects
Young Adult

Grants and funding

K08MH068540/MH/NIMH NIH HHS/United States