Pseudomonas aeruginosa biofilms: mechanisms of immune evasion

Adv Appl Microbiol. 2014;86:1-40. doi: 10.1016/B978-0-12-800262-9.00001-9.

Abstract

The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic fibrosis patients. P. aeruginosa is believed to persist in the host organism due to its capacity to form biofilms, which protect the aggregated, biopolymer-embedded bacteria from the detrimental actions of antibiotic treatments and host immunity. A key component in the protection against innate immunity is rhamnolipid, which is a quorum sensing (QS)-regulated virulence factor. QS is a cell-to-cell signaling mechanism used to coordinate expression of virulence and protection of aggregated biofilm cells. Rhamnolipids are known for their ability to cause hemolysis and have been shown to cause lysis of several cellular components of the human immune system, for example, macrophages and polymorphonuclear leukocytes (PMNs). In this chapter, the interplay between P. aeruginosa and the PMNs in chronic infections is discussed with focus on the role of rhamnolipids and extracellular DNA.

Keywords: Biofilms; Chronic infections; PMNs; Pseudomonas aeruginosa; Rhamnolipids; eDNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biofilms*
  • Glycolipids / immunology
  • Humans
  • Immune Evasion*
  • Neutrophils / immunology
  • Neutrophils / microbiology
  • Pseudomonas Infections / immunology
  • Pseudomonas Infections / microbiology*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / immunology
  • Pseudomonas aeruginosa / physiology*
  • Quorum Sensing

Substances

  • Glycolipids
  • rhamnolipid