Renal angiotensin-converting enzyme and blood pressure control

Curr Opin Nephrol Hypertens. 2014 Mar;23(2):106-12. doi: 10.1097/01.mnh.0000441047.13912.56.


Purpose of review: This review presents novel findings regarding the renal angiotensin-converting enzyme (ACE) and its role in blood pressure (BP) control.

Recent findings: The textbook flow diagram of the renin-angiotensin system (RAS) shows the pulmonary endothelium as the main source of the ACE that converts angiotensin I to angiotensin II. However, ACE is made in large quantities by the kidneys, which raises the important question of what precisely is the function of renal ACE? Recent studies in gene-targeted mice indicates that renal ACE plays a dominant role in regulating the response of the kidney to experimental hypertension. In particular, renal ACE and locally generated angiotensin II affect the activity of several key sodium transporters and the induction of sodium and water retention resulting in the elevation of BP.

Summary: New experimental data link the renal ACE/angiotensin II pathway and the local regulation of sodium transport as key elements in the development of hypertension.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin II / metabolism
  • Animals
  • Blood Pressure*
  • Body Water / metabolism
  • Humans
  • Hypertension / enzymology*
  • Hypertension / physiopathology
  • Kidney / enzymology*
  • Kidney / physiopathology
  • Peptidyl-Dipeptidase A / metabolism*
  • Renin-Angiotensin System*
  • Signal Transduction
  • Sodium / metabolism
  • Water-Electrolyte Balance
  • Water-Electrolyte Imbalance / enzymology
  • Water-Electrolyte Imbalance / physiopathology


  • Angiotensin II
  • Sodium
  • ACE protein, human
  • Peptidyl-Dipeptidase A