Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jan;141(2):245-52.
doi: 10.1242/dev.098269.

How to Make a Primordial Germ Cell

Affiliations
Free article
Review

How to Make a Primordial Germ Cell

Erna Magnúsdóttir et al. Development. .
Free article

Abstract

Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through germ cells. PGCs are specified during early mammalian postimplantation development, and are uniquely programmed for transmission of genetic and epigenetic information to subsequent generations. In this Primer, we summarise the establishment of the fundamental principles of PGC specification during early development and discuss how it is now possible to make mouse PGCs from pluripotent embryonic stem cells, and indeed somatic cells if they are first rendered pluripotent in culture.

Keywords: Epigenetic programming; Primordial germ cells; Specification; Transcription factors.

Similar articles

See all similar articles

Cited by 28 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback