The role of obesity in gastrointestinal cancer: evidence and opinion

Therap Adv Gastroenterol. 2014 Jan;7(1):38-50. doi: 10.1177/1756283X13501786.


There is increasing recognition of the impact of being overweight and obese on the development of cancers at diverse sites including the gastrointestinal tract. Large epidemiological studies indicate that up to 14% of tumours may be related to obesity. Pathophysiological mechanisms underpinning this association are not well understood and so are discussed in this review.

Keywords: adipose tissue, carcinogenesis; inflammation; signalling pathways; visceral adiposity.

Publication types

  • Review