Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion

Br J Nutr. 2014 Jun;111 Suppl 1:S16-22. doi: 10.1017/S0007114513002250.


The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca²⁺) and L-amino acids. The CaSR is expressed in a number of specialised cells within the gastrointestinal (GI) tract, and much work has been done to examine CaSR's role as a nutrient sensor in this system. This review article examines two emerging roles for the CaSR within the GI tract--as a mediator of kokumi taste modulation in taste cells and as a regulator of dietary hormone release in response to L-amino acids in the intestine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Animals
  • Calcium / metabolism*
  • Gastrointestinal Hormones / metabolism*
  • Gastrointestinal Tract / metabolism*
  • Humans
  • Intestinal Mucosa / metabolism
  • Nutritional Status*
  • Receptors, Calcium-Sensing / metabolism*
  • Taste Buds / metabolism
  • Taste Perception
  • Taste*


  • Amino Acids
  • Gastrointestinal Hormones
  • Receptors, Calcium-Sensing
  • Calcium