Circulating Th2 memory cells in IgG4-related disease are restricted to a defined subset of subjects with atopy

Allergy. 2014 Mar;69(3):399-402. doi: 10.1111/all.12342. Epub 2013 Dec 31.


IgG4-related disease (IgG4-RD) is characterized by a lymphoplasmacytic infiltrate composed of IgG4(+) plasma cells, tumefactive lesions, obliterative phlebitis, and mild to moderate eosinophilia. It has been suggested that IgG4-RD is characterized by allergic manifestations and is potentially driven by enhanced T-helper type 2 (Th2) responses. We aimed to investigate the potential contribution of atopy to enhanced Th2 responses in IgG4-RD. Peripheral blood mononuclear cells from 39 patients were isolated and subjected to in vitro mitogenic stimulation with PMA and ionomycin. Following stimulation, gated CD3(+) CD4(+) T cells were analyzed for production of the Th2 cytokines IL-4, IL-5, and IL-13. Among the 39 patients analyzed, only the 18 patients who had a history of atopy showed increases in circulating Th2 memory cells. Our results indicate that Th2 responses that have been reported in IgG4-RD may result from concomitant atopic manifestations in disease subjects.

Keywords: IgG4-RD; Th2 response; allergy; atopy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Hypersensitivity, Immediate / diagnosis
  • Hypersensitivity, Immediate / immunology*
  • Immunoglobulin G / immunology*
  • Immunologic Memory*
  • Immunophenotyping
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Phenotype
  • Th2 Cells / immunology*
  • Th2 Cells / metabolism
  • Young Adult


  • Immunoglobulin G