Ubiquitylation and control of renal Na+ balance and blood pressure

Physiology (Bethesda). 2014 Jan;29(1):16-26. doi: 10.1152/physiol.00021.2013.


Ubiquitylation is crucial for regulating numerous cellular functions. In the kidney, ubiquitylation regulates the epithelial Na(+) channel ENaC. The importance of this process is highlighted in Liddle's syndrome, where mutations interfere with ENaC ubiquitylation, resulting in constitutive Na(+) reabsorption and hypertension. There is emerging evidence that NCC, involved in hypertensive diseases, is also regulated by ubiquitylation. Here, we discuss the current knowledge and recent findings in this field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Pressure / genetics
  • Blood Pressure / physiology*
  • Humans
  • Hypertension / physiopathology*
  • Kidney / metabolism
  • Sodium / metabolism*
  • Sodium Channels / physiology*
  • Ubiquitination / physiology*


  • Sodium Channels
  • Sodium