Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease

doi:10.1155/2013/986254

. 2013:2013:986254.

doi: 10.1155/2013/986254. Epub 2013 Dec 8.

Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease

Abdulkadir Koçer¹, Aslı Yaman², Elvin Niftaliyev², Hümeyra Dürüyen², Mehmet Eryılmaz³, Emel Koçer²

Affiliations

¹ Medical Faculty, Istanbul Medeniyet University, Istanbul, Turkey ; Düzce University, Düzce, Turkey.
² Bezmialem Vakıf University, Istanbul, Turkey.
³ Düzce University, Düzce, Turkey.

PMID: 24382959
PMCID: PMC3870626
DOI: 10.1155/2013/986254

Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease

Abdulkadir Koçer et al. Curr Gerontol Geriatr Res. 2013.

. 2013:2013:986254.

doi: 10.1155/2013/986254. Epub 2013 Dec 8.

Authors

Abdulkadir Koçer¹, Aslı Yaman², Elvin Niftaliyev², Hümeyra Dürüyen², Mehmet Eryılmaz³, Emel Koçer²

Affiliations

¹ Medical Faculty, Istanbul Medeniyet University, Istanbul, Turkey ; Düzce University, Düzce, Turkey.
² Bezmialem Vakıf University, Istanbul, Turkey.
³ Düzce University, Düzce, Turkey.

PMID: 24382959
PMCID: PMC3870626
DOI: 10.1155/2013/986254

Abstract

Platelets induce chronic inflammation which is a key step in atherosclerosis and may be involved in the progression of neurodegenerative diseases (NDD). We aimed to measure the mean platelet volume (MPV) and platelet count (PLC) in NDD patients. The present study was designed to investigate the platelet function by measuring MPV and PLC in NDD. A total of 182 outpatients with Alzheimer's (AD) or Parkinson's diseases (PD) were included. The control group consisted of 104 healthy subjects. Platelet count was similar between groups. MPV values of PD patients were higher than those of AD patients and controls (P < 0.001). MPV correlated negatively with Heohn and Yahr scale (HYS) score (P < 0.001). Increased MPV in patients with PD may point to a platelet dysfunction. High-grade inflammation presents with low levels of MPV as seen in PD patients with high HYS scores.

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Figures

**Figure 1**
Comparison of mean platelet volume (MPV) values.

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References

1. Borroni B, Akkawi N, Martini G, et al. Microvascular damage and platelet abnormalities in early Alzheimer’s disease. Journal of the Neurological Sciences. 2002;203-204:189–193. - PubMed
1. Qiu C, Hu G, Kivipelto M, et al. Association of blood pressure and hypertension with the risk of parkinson disease: the National FINRISK study. Hypertension. 2011;57(6):1094–1100. - PubMed
1. Pluta R, Ulamek M, Jablonski M. Consideration of the ischaemic basis and treatment of Alzheimer's disease. Folia Neuropathologica. 2010;48(1):11–26. - PubMed
1. Pluta R, Ułamek M, Jabłoński M. Alzheimer's mechanisms in ischemic brain degeneration. The Anatomical Record. 2009;292(12):1863–1881. - PubMed
1. Tesco G, Koh YH, Kang EL, et al. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity. Neuron. 2007;54(5):721–737. - PMC - PubMed

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[1] Borroni B, Akkawi N, Martini G, et al. Microvascular damage and platelet abnormalities in early Alzheimer’s disease. Journal of the Neurological Sciences. 2002;203-204:189–193. - PubMed

[2] Borroni B, Akkawi N, Martini G, et al. Microvascular damage and platelet abnormalities in early Alzheimer’s disease. Journal of the Neurological Sciences. 2002;203-204:189–193. - PubMed

[3] Qiu C, Hu G, Kivipelto M, et al. Association of blood pressure and hypertension with the risk of parkinson disease: the National FINRISK study. Hypertension. 2011;57(6):1094–1100. - PubMed

[4] Qiu C, Hu G, Kivipelto M, et al. Association of blood pressure and hypertension with the risk of parkinson disease: the National FINRISK study. Hypertension. 2011;57(6):1094–1100. - PubMed

[5] Pluta R, Ulamek M, Jablonski M. Consideration of the ischaemic basis and treatment of Alzheimer's disease. Folia Neuropathologica. 2010;48(1):11–26. - PubMed

[6] Pluta R, Ulamek M, Jablonski M. Consideration of the ischaemic basis and treatment of Alzheimer's disease. Folia Neuropathologica. 2010;48(1):11–26. - PubMed

[7] Pluta R, Ułamek M, Jabłoński M. Alzheimer's mechanisms in ischemic brain degeneration. The Anatomical Record. 2009;292(12):1863–1881. - PubMed

[8] Pluta R, Ułamek M, Jabłoński M. Alzheimer's mechanisms in ischemic brain degeneration. The Anatomical Record. 2009;292(12):1863–1881. - PubMed

[9] Tesco G, Koh YH, Kang EL, et al. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity. Neuron. 2007;54(5):721–737. - PMC - PubMed

[10] Tesco G, Koh YH, Kang EL, et al. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity. Neuron. 2007;54(5):721–737. - PMC - PubMed

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Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease

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Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease

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